You've probably heard of it, if you've been with Pokemon long enough. It's basically a challenge you set yourself to make the game harder. There are 2.5 solid rules that you must follow to qualify the challenge as Nuzlocke. 1) If a Pokemon faints it is considered 'dead', and you must release it as soon as possible. 2) You may only catch one pokemon per 'area'(route, cave, city) of the game, and it has to be the first one you see. .5) Every Pokemon you catch must be nicknamed (not required, but advised) Other rules are accepted, such as limited usage of items/Pokemon centers/Pokemon. For example, the current run I'm doing is a no item run. If I wanted to challenge myself more, I could give myself the restriction of two uses of Pokemon Centers per town, or only let myself buy one Poke ball per town. I've seen people do mono-type runs, where you can only catch Pokemon of a certain type(and only if you see them first in the area!). It's named Nuzlocke for the original Nuzlocke playthrough, where the first Pokemon caught was a Seedot, which evolved into the mascot for the challenge(and died). There is a comic about this player's travels, too. Do it, guys. It's fun. Especially if you give your pokemon names of your family members.